TrkB Downregulation Is Required for Dendrite Retraction in Developing Neurons of Chicken Nucleus Magnocellularis
نویسندگان
چکیده
منابع مشابه
TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis.
The chick embryo (Gallus domesticus) is one of the most important model systems in vertebrate developmental biology. The development and function of its auditory brainstem circuitry is exceptionally well studied. These circuits represent an excellent system for genetic manipulation to investigate mechanisms controlling neural circuit formation, synaptogenesis, neuronal polarity, and dendritic a...
متن کاملTonotopic gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis.
Nucleus magnocellularis (NM) is a division of the avian cochlear nucleus that extracts the timing of auditory signals. We compared the membrane excitability and synaptic transmission along the tonotopic axis of NM. Neurons expressed a Kv1.1 potassium channel mRNA and protein predominantly in the high characteristic frequency (CF) region of NM. In contrast, the expression of Kv1.2 mRNA did not c...
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Neurons of nucleus magnocellularis (NM), a division of avian cochlear nucleus that performs precise temporal encoding, receive glutamatergic excitatory input solely from the eighth nerve and GABAergic inhibitory input primarily from the ipsilateral superior olivary nucleus. GABA activates both ligand-gated Cl- channels [GABA(A) receptors (GABA(A)Rs)] and G protein-coupled receptors (GABA(B) rec...
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GABAergic modulation of activity in avian cochlear nucleus neurons has been studied extensively in vitro. However, how this modulation actually influences processing in vivo is not known. We investigated responses of chicken nucleus magnocellularis (NM) neurons to sound while pharmacologically manipulating the inhibitory input from the superior olivary nucleus (SON). SON receives excitatory inp...
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4- to 8-day-old chicks were used to examine the ultrastructure of end bulbs and neurons of nucleus magnocellularis by freeze-fracture and thin section techniques. Both normal animals and animals deafferented by removal of the basilar papilla were used to describe the pre- and postsynaptic membranes of these neurons. Postsynaptic membrane specializations similar to those described in rodents wer...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2274-12.2012